#FUNCTIONALIZED CORE SHELL NANOPARTICLES HOW TO#

#FUNCTIONALIZED CORE SHELL NANOPARTICLES HOW TO#

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L-Arginine/ L-lysine functionalized chitosan–casein core–shell and pH-responsive nanoparticles: fabrication, characterization and bioavailability enhancement of hydrophobic and hydrophilic bioactive compounds This work offers a novel approach for producing core–shell and pH-responsive nanocarriers for oral delivery and bioavailability enhancement of both hydrophobic and hydrophilic bioactive compounds. The simulated gastrointestinal digestion experiments confirmed that curcumin and EWDP had higher bioaccessibility in Arg/Lys-CS–CA NPs. Nano Ward Arm Gear provides 44 defense, 90 stability and consumes 5 Core Power. The in vitro controlled release profile of the core–shell NPs was obtained up to 24 and 48 h for curcumin and EWDP, respectively. Hard Shells Liquid Armour is the worlds most innovative coating. Functionalization can be either through a ligand exchange reaction or using modified thiol as the capping agent in the Brust method. Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry analysis were conducted to fully characterize the interaction mechanism of Arg/Lys-CS with CA, as well as the NP incorporation with curcumin and EWDP. The synthesis of functionalized nanomaterials has been receiving considerable attention during the past few years. In this paper, the structure of the magnetic core-shell nanoparticles functionalized by an imide group was investigated by a simple co-precipitation method. The encapsulation efficiency of curcumin and EWDP in the NPs ranged from 81–91%, 35–74% in Arg-CS–CA NPs, and 76–87%, 48–87% in Lys-CS–CA NPs varying with different pH values. Dynamic light scattering and transmission electron microscopy examination revealed Arg/Lys-CS–CA NPs with the smallest particle size of 110/82 nm, pH-responsive properties, excellent storage stability until 28 days, and spherical shape. The assembled casein (CA) was modified by NaOH and used as a template core for affinity binding with hydrophobic curcumin and hydrophilic egg white-derived peptides (EWDP) and then coated with Arg- or Lys-functionalized chitosan (CS) to stabilize the systems via electrostatic interaction. Therefore, these N-halamine-functionalized silica-polymer core-shell nanoparticles have the potential for various significant applications such as in medical devices, healthcare products, water purification systems, hospitals, dental office equipment, food packaging, food storage, household sanitation, etc.This study aimed at developing novel oral self-assembled delivery systems for the encapsulation, protection, and controlled release of hydrophobic and hydrophilic bioactive compounds based on L-arginine (Arg)- or L-lysine (Lys)-functionalized chitosan–casein nanoparticles (NPs). These N-halamine-functionalized silica-polymer core-shell nanoparticles displayed powerful antibacterial performance against both Gram-positive bacteria and Gram-negative bacteria, and their antibacterial activities have been greatly improved compared with their bulk counterparts. The as-synthesized nanoparticles were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive x-ray spectrometry (EDX), dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier transform infrared (FTIR). N-halamine-functionalized silica-polymer core-shell nanoparticles with enhanced antibacterial activity were synthesized through the encapsulation of silica nanoparticles as support with polymeric N-halamine.

Functionalized core shell nanoparticles